The simple, accurate and precise simultaneous equation method has been developed for the simultaneous estimation of cefuroxime axetil and linezolid in combined tablet dosage form. The method utilizes methanol as solvent and λmax of cefuroxime axetil and linezolid selected for analysis were found to be 281 nm and 250 nm respectively. The method was validated as per international conference on harmonization (ICH) guidelines. The linearity range lies between 2-10 μg/ml (R2 0.9996) for cefuroxime axetil and 2.4-12 μg/ml (R2 0.9998) for linezolid. The accuracy and precision were determined and found to comply with ICH guidelines. The method showed good reproducibility and recovery with % RSD in desired range. The proposed method can be applied for routine analysis of both drugs.
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